The Biogenesis of Orotic Acid in Liver Slices.
نویسندگان
چکیده
منابع مشابه
Apolipoproteins of the orotic acid fatty liver: implications for the biogenesis of plasma lipoproteins.
Rats fed orotic acid develop fatty livers characterized by triglyceride-laden, membrane-bounded vesicles designated "liposomes." We have measured the levels of apolipoproteins in isolated liposomes and other subcellular fractions by SDS-polyacrylamide gel electrophoresis, electrotransfer, and immunodecoration. Apolipoproteins Bh, Bl, E, and C appear to cofractionate; for these proteins, the lip...
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Other studies in this laboratory (1) drew our attention to the possibility that erotic acid might be concerned with the maintenance of adequate lactation in the rat and with the survival of the young. Since no data were available on the erotic acid content of milk, this study was undertaken. The occurrence of erotic acid as a component of milk has been indicated since 1904, when Biscaro and Bel...
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Odd carbon fatty acids are considered to be oxidized in tissue by successive fl oxidation in much the same way that even carbon members of the series are (14). The terminal S-carbon unit has been investigated to some extent. Atchley (5) demonstrated propionic acid as an end-product in the oxidation of valeric acid by a rabbit enzyme system. Studies on malonate inhibition with odd carbon fatty a...
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The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1% OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days. Serum lipid profiles were measured using enzyme assay kits. Lipids of liver tissues were extracted and liver lipid contents were determined. A peach of liver was prepared to determine the activities ...
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The effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed with orotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control. The liver malondialdehyde (MDA) content increased by 10%, but the gluthation peroxidase (GSH-Px) activity decreased by 50%. The serum aspartate aminotransferase (AST) and...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1953
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.07-1207